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This is a common, but plausible statement to explain low in vitro-activities or salt sensitivities, because most of the antimicrobial peptides are produced for acting in short time intervals and after release from storage granules the peptides can locally reach remarkable high amounts as known from defensins [116]

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This proximal position of the RAMP2 ECD is conserved in AMY 2 R complexes bound to CT peptides that also have a C-terminal Pro (P32 CT ) (Fig

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