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Based on the derived sensitivity and specificity, performance metrics including positive predictive value, negative predictive value, number needed to screen, and number proceeding to PET scan were calculated based on a prevalence of amyloid PET positivity of 25% 31

Reserve primary research for high-value validation and gap-filling

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This is because hemoglobin A1C (a measure of blood sugar control) and sex hormone-binding globulin (SHBG) are inversely correlated: as A1C improves with weight loss, SHBG levels may rise, which can bind more testosterone and reduce the amount that circulates freely in the bloodstream

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