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These maladaptive changes establish a pathological feedback loop: ROS accumulation triggers mitochondrial fragmentation and mitophagy dysregulation, which in turn promotes further ROS production ( 5.3 ROS-activated signaling pathways in muscle atrophy Following rotator cuff injury, the supraspinatus undergoes chronic functional unloading due to tendon discontinuity and compensatory recruitment of adjacent muscles

Work continued there until 11 October, when she was towed to the Norfolk Naval Shipyard for completion of the yard work

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Biomolecules 7, 16