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103 While potent skin sensitizers have long been used in treatment of warts and alopecia aerata, 237239 haptenation is generally avoided in drug discovery because of the fear of potential immunotoxicity associated with off-target covalent binding

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Evidence from animal models supports this, showing that mice fed KD exhibit lower ROS production compared to mice on a standard diet, thereby demonstrating the systemic effect of this dietary intervention [68]