Additionally, CHAC1 downregulation results in increased levels of ferroptosis inhibitors such as GPX4 and SLC7A11, underscoring its pivotal role in controlling ferroptosis and its potential as a therapeutic target in bladder cancer ( 6.6 Liver cancer Hepatocellular carcinoma (HCC) is a prevalent and deadly form of liver cancer with a high incidence of recurrence and metastasis
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doi: 10.1016/j.scib.2020.12.035 415 TorosantucciA.BromuroC.ChianiP.De BernardisF.BertiF.GalliC.et al
Briefly, mice received a single, blinded intraperitoneal injection of either vehicle control (2% DMSO in 0.9% NaCl) or dexamethasone (200 g/kg in 0.9% NaCl) in a final volume of 200 l ice-cold solution, administered 30 min prior to surgery
Previous studies have demonstrated that rapamycin, an inhibitor of mTOR, reduces GPX4 protein expression and promotes ferroptosis and autophagy 9,10
