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7 Pharmacological Reviews Amylin pharmacologyHay DL et al

Cagrilintide is engineered to last far longer than natural amylin, so the satiety signal stays switched on

Occupancy stays low, but each engaged receptor keeps sending its main message longer than it would under a balanced signal (cAMP bias with low receptor internalization). In a head-to-head trial against liraglutide, tirzepatide reduced measured food intake and craving more despite lower GLP-1 occupancy. The effect lowers the drive to eat rather than increasing restraint

There is no Therapeutic Use Exemption pathway for an unapproved substance

In some embodiments, the otic formulation or composition comprises about 0.01% by weight of the povidone