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A recent study using a partial sample (total N = 9631, consisting of individuals who currently smoke n = 399, no longer smoke n = 3322, and who have never smoked n = 5910) from the UK Biobank looking at several cardiovascular risk factors found that a greater number of cigarette pack years (i.e., cigarettes per day divided by 20 and then times the number of years smoked) was associated with reduced total gray matter volume and reduced volume of the thalamus, basal ganglia, hippocampus, and several cortical regions [14]

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The data also showed that stopping smoking is worthwhile: the longer ago the last cigarette was smoked, the lower the risk of developing depression