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It is important to distinguish between medically indicated B12 injections prescribed for deficiency and lipotropic injections, which are typically unlicensed medicines in the UK and lack robust clinical evidence for weight loss

Hydroxocobalamin: Adverse reactions (IV use)

Side effects of tirzepatide with B12 and management strategies Gastrointestinal side effects dominate the adverse event profile

Lipo B12 injections may help boost mood and reduce symptoms of depression when taken under medical guidance

So, you measure a higher B12, but part of that B12 is inactive, so useless Oral B12 supplementation, even in the form of a multivitamin preparation, may result in serum B12 concentrations just within the normal range without abolishing symptoms