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It presents with a broad clinical spectrum, ranging from asymptomatic or non-specific symptoms, such as fatigue or lightheadedness, to severe manifestations, including nausea, vomiting, alteration of consciousness, and even coma, which can be life-threatening 3,4

The role of NADPH, the reduced form of nicotinamide adenine dinucleotide phosphate (NADP + ), in mediating inflammatory and anti-inflammatory responses in activated myeloid cells has been well-established in the past decades

In addition, the observed side-chain flexibility of V12 and F112 indicated that these residues are mainly involved in the overall shaping of the active site and help to position the flavonoid substrate in accordance with the presented structural evidence

The American Journal of Geriatric Psychiatry

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