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Taurine is involved in mitochondrial homeostasis via its ability to act as a mitochondrial matrix pH buffer, by regulating mitochondrial potential, by modulating Ca 2+ -induced mitochondrial swelling, and by regulating the activity of mitochondrial dehydrogenases and ATP concentration

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Two preclinical studies showed benefits of ascorbate in a familial ALS mouse model, and there are two case reports indicated that ascorbate was associated with improvement of the disease

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