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"Insulin-like growth factor 1 and muscle growth: implication for satellite cell proliferation." Proceedings of the Nutrition Society, 63(2), 337-340

1 Introduction Melasma is a common hyperpigmentation disorder, especially in the female gender, that is usually presented symmetrically as light brown to dark brown hyperpigmented spots in the face and also it can be exacerbated through prolonged sun exposure (Espsito et al., 2022)

Current adult dosing rests on practitioner experience and published reviews rather than fresh Phase 3 trials

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J Cell Physiol 237:18451856 Joerger M, Huitema A, Illerhaus G, Ferreri A (2012) Rational administration schedule for high-dose methotrexate in patients with primary central nervous system lymphoma