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This protease-driven nerve activation is now believed to be a major contributor to the visceral hypersensitivity and widespread "nociplastic" pain seen in conditions like irritable bowel syndrome (IBS), ME/CFS, and fibromyalgia

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Phytotherapy Research, 23 (3), 367-372

The same research group (279) subsequently isolated and identified 148 bacterial strains from CKD patient feces, of which 92 were uremic toxin precursor-generating bacteria

Observations further propose that it might decrease iron release from ferritin, which could reduce oxidative activity within damaged tissue environments