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The primary antioxidant defense in cells is mediated through enzymatic and non-enzymatic systems, including factors such as glutathione (GSH), glutathione peroxidase (GPX), catalase (CAT), and superoxide dismutase (SOD) ( The Keap1-Nrf2 signaling pathway plays a crucial role in mediating the antioxidant system

Increasing the ingested dose above 5 g should be avoided since this will alter intestinal motility and water handling through its osmotic effect

Mindfulness-Based Stress Reduction (MBSR), Mindfulness-Based Cognitive Therapy (MBCT), and stress management skills training have shown potential in some studies to alleviate fatigue, improve emotional well-being, and modulate diurnal cortisol rhythms (Stubhaug et al., 2018

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Moreover, some ATF members can directly or indirectly recruit ATP-dependent chromatin-remodeling complexes, altering nucleosome positioning and conformation to reorganize the chromatin landscape (112)