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Otto Heinrich Warburg, who was awarded the Nobel Prize in 1931 for his discovery [4]

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Inadequate function of methionine synthase can lead to an accumulation of homocysteine, which has been associated with increased risk of cardiovascular disease and age-related neurodegenerative disease (e.g., Alzheimers disease)

doi: 10.1016/s0015-0282(02)04679-4