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This size separation enables researchers to determine how different chemicals including nicotine, tar, and carcinogens reach specific regions of the respiratory system, from the throat to the alveoli

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The frailty analysis we performed aimed to test if the results obtained from the MR analysis in this study could be explained by the effects of frailty alone, in which a survival bias due to selective mortality was responsible for the causal estimate between either alcohol consumption or smoking continuation and PD risk

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