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549 Chronic pain and disability associated with DPN can lead to significant psychological distress

For example, damage-associated molecular patterns (DAMPs) or KRAS G12D proteins released from ferroptotic cells can be packaged into exosomes and internalized by macrophages, transforming them into the M2-like phenotype and leading to an immunosuppressive environment [118]

In addition to the filter paper, the same diameter circle sheets of cellulose cooking paper (Lion, Tokyo, Japan) and unwoven sheet cut out from surgical mask 73622-01 (As One Corporation, Osaka, Japan) were used for immobilization as sheet-type carrier

Laminin synthesis slows