Selective NNMT inhibition as a strategy for metabolic disease
L.MemoM
Correspondingly, ZD results in developmental retardation of children, delayed genital development and hypogonadism, skin disorders, hair loss, teratogenic effects, as well as weakened immune function, leading to an increased susceptibility to infections
In addition, the presence of the antioxidant N-acetylcysteine or P-gp ATPase inhibitor, PSC-833, reverse the collateral sensitivity of resistant cells to tamoxifen
5a, the pretreatment with Src inhibitor (SKI-1) significantly reduced the effect of BPC 157 on the phosphorylation of Src, Cav-1 and eNOS, further confirming the critical upstream role of Src in this pathway