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GPX4 is broadly expressed across tissues, with high levels in the testis, where it is essential for spermatogenesis 97

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SRGN encodes for a proteoglycan in hematopoietic cells 26 and its overexpression is associated with poor prognosis in hepatocellular 50 , colorectal cancer 51 , non-small cell lung cancer 52 , and nasopharyngeal carcinoma 53

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These studies help clarify how IGF-1 regulates nutrient use and energy balance in controlled experiments

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