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Cardiovascular and vascular calcification: MOTS-C exposure has been reported to reduce oxidative stress, improve vascular wall structure, decrease disordered elastic fibers, and attenuate vascular calcification and endothelial dysfunction
Chang and colleagues showed in 2011 that the peptide upregulates growth-hormone receptor expression on tendon fibroblasts and increases their migration and survival in culture, an effect that has been reproduced across several Achilles- and quadriceps-tendon transection models in rats
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