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The decision to continue, reduce the dose, or discontinue should be based on individual response and goals

In the context of early brain injury following subarachnoid hemorrhage (SAH), topiramate significantly reduced the elevated levels of TNF-, IL-1, and IL-6 induced by SAH, suggesting that topiramate may exert neuroprotection via its anti-inflammatory effects (Tian et al., 2015)

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Histone acetylation: a switch between repressive and permissive chromatin