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doi: 10.1016/j.yexcr.2020.112061

Although there have been a limited number of studies, we found that when normalized for neuronal volume using the MRS biomarker N-acetyl aspartate, there is clear evidence for an elevation of glutamate in the early progression of ALS which is consistent with the predictions of the model of increased activity of glutamatergic neurons leading to excitotoxicity