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Acknowledgements This work was supported by the National Natural Science Foundation of China [grant numbers 82125037], Science Foundation for Distinguished Young Scholars of Jiangsu province [grant number BK20231528], Key R&D Program of Jiangsu Province [grant number BE2022815], Jiangsu Provincial Medical Innovation Center [grant number CXZX202225], Young Elite Scientists Sponsorship Program of the China Association for Science and Technology [grant number 2021-QNRC2-B17], and 333 high-level talents project of Jiangsu Province for Yang Yang [grant number BRA202202]

the label also warns that rash, hives, or swelling of the face, mouth, lips, or tongue can signal a hypersensitivity reaction requiring emergency care, though no generalized allergic reactions were documented in the original trials Because current supply comes only from compounded preparations rather than an FDA-verified finished product, potency, purity, and sterility can vary by pharmacy, and unregulated online sources carry added contamination or mislabeling risk
The idea of broadly surveying the metabolic environment of patients is certainly not new, despite the changes in terminology over the years