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Proven alternatives deliver comparable results with established safety: tirzepatide monotherapy produces 15-22% weight loss with FDA approval and extensive clinical data, while CagriSema (cagrilintide + semaglutide) delivers 15-25% weight loss with Phase 3 trial validation and clearer path to medical acceptance

These washout periods, which have been updated slightly since the 2022 List documents were published on 30 September to incorporate the latest scientific information, are highlighted in the revised version of the Summary of Major Modifications and Explanatory Note, and are based on the use of these medications according to the maximum manufacturers licensed doses

Once an antioxidant like Vitamin E or Vitamin C neutralizes a free radical, it becomes unstable itself

This cascade of effects ultimately results in lower overall sulfite levels, despite riboflavins role in the initial conversion of H2S to sulfite