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Antibiotic Therapy When it comes to guidelines, the European Alliance of Associations for Rheumatology (EULAR) recommendations acknowledge that gastrointestinal involvement, including SIBO, is common in systemic sclerosis and suggest sequential or rotating courses of antibiotics as the main therapy, but there is no consensus on the optimal agent, dose, or duration [1]

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doi:10.1371/journal.pone.0033944 Lederman RJ, Mendelsohn FO, Anderson RD, Saucedo JF, Tenaglia AN, Hermiller JB, Hillegass WB, Rocha-Singh K, Moon TE, Whitehouse MJ et al (2002) Therapeutic angiogenesis with recombinant fibroblast growth factor-2 for intermittent claudication (the TRAFFIC study): a randomised trial