With age, SIRT1 levels decline, disrupting the molecular clock in the SCN and thereby impairing both circadian and metabolic homeostasis ( 3.4 Effects of aging and sleep on the glymphatic system and neuron-glial redox coupling in brain health Aging also impairs the glymphatic system, a crucial brain-wide clearance network responsible for removing interstitial waste products, including neurotoxic and ROS-generating protein aggregates such as amyloid-, -synuclein, and neurofibrillary tangles (Rasmussen et al., 2018
[ 13 ] Cortisol, often referred to as the body's primary stress hormone, normally follows an opposite pattern to melatonin, rising in the morning and declining throughout the day
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The stress of day-to-day life can negatively affect the immune system and overall, well-being
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