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Additionally, if a peptide is pH-sensitive, use a buffer that will maintain a stable pH (e.g., 10 mM acetate buffer for pH ~5, or a mild PBS for pH ~7.4)

The combination of anti-angiogenic therapy and anti-PD-1 immunotherapy has been found to effectively overcome drug resistance in breast cancer 64

doi: 10.1038/nature14156 112 MotwaniMFitzgeraldKA

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This delivery method bypasses the gastrointestinal system altogether, so persons in risk groups for vitamin B12 deficiency with gastrointestinal issues may turn to the shot option for a quick means of ensuring their body has sufficient stores of vitamin B12 to effectively function