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Future investigations should integrate animal models and in vitro systems to systematically analyze the dynamic relationship between ferroptosis biomarkers and specific histone modification patterns (e.g., H3K9me3, H3K27me3) across different stages of the disease

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4 Following a cartilage injury, the stimulation of catabolic influences such as post-inflammatory cytokines encompassing tumor necrosis factor (TNF-) and IL-1 are involved in the development of OA

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