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The IGF axis has been shown to play roles in the promotion of cell proliferation and the inhibition of cell death (apoptosis)

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As expected GTP-bound open conformer has the smallest LRC and highest DOFs among all the three structures, referring to formation and activation of allosteric network through conformational rearrangements of LRC residues on the onset of GTP binding

Acknowledgments Thanks to GAIN (Axencia Galega de Innovacin) for supporting this research (grant number IN607A2019/01)

When IGF-1 receptors become less sensitive or when IGF-1 is not produced in sufficient quantities the entire somatotropic feedback system is affected