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(1979) also reported that following intravenous Alcian blue injection in fetal sheep, the dye (which is electron-dense and binds to plasma albumin) could be seen within numerous vesicles and tubules in the cytoplasm of the endothelial cells

They are the main entry route for molecules into the CNS as well as the major hurdle that impedes most neuropharmaceuticals from eliciting a desired pharmacological effect at an obtainable dose