doi:10.1007/s00213-024-06735-1 Richie JP Jr, Nichenametla S, Neidig W, Calcagnotto A, Haley JS, Schell TD, Muscat JE
Potential adverse effects related to chronic GH/IGF-1 elevation represent an important theoretical concern
The data shown reflect the detection of their corresponding NEM adducts (for example, NEM-cystine, NEM-cysteinylglycine and NEM-GSH)
In PD investigation, multiple preclinical studies have claimed that prior exposure (for different periods of time, from one week to three weeks) of experimental animals (mice, rats) to caffeine reduced the loss of dopaminergic neuronal mass in the striatal area in a dose-dependent manner (30 mg/kg, 10 mg/kg 1 g/L in drinking water), thus conferring the neuroprotective effect [94,95]
[DOI] [PMC free article] [PubMed] [Google Scholar] 73.Filippatos GS, Ahmed MI, Gladden JD, Mujib M, Aban IB, Love TE, et al