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Dual GIP and GLP-1 receptor agonist GLP2 improves beta-cell function and insulin sensitivity in type 2 diabetes

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The CesAs terminal C domain is proposed to work in trans with the D- O -Leu-D-Ala peptide as donor and the hydroxy group of the CesB1 PCP-thioester bound L- O -Val, followed by CesB2 PCP-bound L-Val as nucleophilic acceptors 8

Comparison of herniated, degenerated, and scoliotic (control) discs Differences between non-degenerated (control) and herniated tissues were similar to differences (described above) between constrained and unconstrained explants (Figs