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While later outfitted with a pacemaker, he's experienced a few cardiac events, once showing off a surgical scar to Homer and noting that his terrible heart problems permanently altered his appearance his pale white face coloring evidently "ain't makeup." In the 2007 episode "Little Big Girl," Krusty laments a "massive organ failure" problem, and he tells Sophie, the daughter he didn't know he had, that diabetes runs in the family

Nehls, Littered cigarette butts as a source of nicotine in urban waters

Premature graying of the hair can occur due to smoking cigarettes

Tobacco itself contained high levels of arsenic until recently, due to the extensive use of arsenic-based pesticides in tobacco farming

Differential changes in accumbens shell and core dopamine in behavioral sensitization to nicotine