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MITF belongs to a family of transcription factors with basic helix-loop-helix leucine zipper structures, which enable them to bind directly to canonical enhancer box (E-BOX) sequences (CA[T/C]GTG)

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doi:10.1016/S0891-5849(99)00176-8 23

News Feature Seeking universal malaria-vaccine targets News & Views

This suggests that the activation of insulitis, which underpins the initiation and progression of diabetes, requires the immune tolerance to -cell autoantigens to be broken (1, 30)