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Weight loss occurs because people eat less, creating an energy deficit that forces the body to use stored fat

A compound affecting so many biological pathways could easily have subtler harms that small trials (or enthusiastic investigators) might miss

Tramutola A, Lanzillotta C, Perluigi M, Allan Butterfield D

Peer-reviewed preclinical literature references BPC-157 in laboratory studies involving angiogenic signaling, nitric oxide pathway interactions, fibroblast migration, collagen synthesis, and gastrointestinal biology

Penetration through the skin barrier is limited, particularly for larger molecules, and results depend heavily on the delivery vehicle and formulation