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The article from Prasse et al suggest[s] that chronic nicotine stimulation induced by cigarette smoking promotes macrophage and Langerhans cell accumulation in the lung via an increase in [osteopontin production]. Osteopontin and cellular receptors for nicotine may therefore be new targets for treating smoking related lung disease

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[DOI] [PubMed] [Google Scholar] Szewczyk K

Furthermore, regulatory changes surrounding tobacco advertising and public smoking are influencing consumer behavior, pushing more smokers toward specialized and premium products