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Acknowledgements This study was supported by P01CA87497 (B.R.S.), R35CA209896 (B.R.S.) and R61NS109407 (B.R.S.), and the BMBF VIP+ program NEUROPROTEKT (03VP04260), the Ministry of Science and Higher Education of the Russian Federation (075-15-2019-1933) and the European Research Council (ERC) under the European Unions Horizon 2020 research and innovation program (grant agreement No