Those patients that have complications that have been shown to be ameliorated by GLP-1-based drugs, and I would say secondary prevention of cardio, of heart attacks for semaglutide
Balestra, A
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Given its high usage and availability as an over-the-counter analgesic, a systematic review of paracetamols efficacy and tolerability in individual conditions is warranted ( On the whole, although there is no direct evidence in COVID-19 patients, PAC is likely to promote GSH depletion, especially in those population groups at higher risk ( The following considerations further strengthen the criticism toward the use of PAC as a safer alternative to NSAID: PAC has been preferred to NSAIDs and steroids for the symptomatic and domiciliary management of the early stages of COVID-19, a choice grounded of the precautionary principle (but still theoretical in this specific case) principle primum non nocere ( Counterintuitively, however, the same precautionary principle has not been applied to PAC itself, and the risks of developing severe COVID-19 associated to the reduction of GSH might be far higher than the benefits derived from discouraging the use of NSAIDs or steroids
The identity of NFT derivatives and/or reactive oxygen species interacting with the Nrf2-Keap1 complex were not identified in the course of the present work, but will be investigated in future studies
