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These antibodies contribute to glandular injury via complement-dependent and antibody-dependent cell-mediated cytotoxicity, and promote the release of cytokines such as IL-6, IL-1, and IL-8, which enhance lymphocyte accumulation and the local inflammatory response

In 2011, Lee et al

The transdermal composition of claim 2 wherein penetration enhancer is selected from one or more of Dimethyl sulfoxide(DMSO), Dimethyl formamide, Ethanol, Propylene glycol, Octyl alcohol, Caprylocaproyl polyoxyl-8 glycerides and diethylene glycol monoethyl ether, Ethyl oleate, Isopropyl myristate , Glyceryl monolaureate, Silicone oil

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