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doi: 10.3389/fonc.2026.1748136 Received 18 November 2025 Revised 23 March 2026 Accepted 24 March 2026 Published 30 April 2026 Volume 16 - 2026 Edited by Pierfranco Conte, University of Padua, Italy Reviewed by Valeria Conti, University of Salerno, Italy T Mohan Viswanathan, Karpagam Academy of Higher Education, India Updates Copyright 2026 Talath, El-Tanani, Wali, Rabbani, Bhongande, Ibraheem, Avagimyan, Hoffmann, Ilias, Ispas, Viviana, Paczkowska and Rizzo

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Unexpectedly, C57BL/6J and C57BL/6N mice showed opposite brain cytoplasmic redox changes with aging, which contrasted with the rat brain or mouse liver that did not show aging-related redox changes in the cytoplasmic [NADPH]/[NADP + ] or [NAD + ]/[NADH]