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Collagen-producing fibroblasts depend on adequate vascular supply to sustain their metabolic demand during active matrix synthesis, making angiogenesis a prerequisite for effective structural repair

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Sharp pain or discomfort persisting overnight indicates excessive stress on healing tissue

For asymptomatic patients with an ALT or AST level that is abnormal but less than 3 times the ULRR or an abnormal bilirubin level less than 1.5 times the ULRR, the checkpoint inhibitor can be continued with biweekly laboratory monitoring

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