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NNMT catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, producing 1-methylnicotinamide (1-MNA)

doi: 10.1016/j.jaad.2014.03.019 140 MashalyMEKotbHMAbdinAAHedyaSE

So having proper glutathione levels is not only an essential, it has become a need in the current environment that we live

Decreased levels of TNF- and IL-6 indicate that NNMT inhibition not only modulates metabolism but also improves the inflammatory microenvironment, a key component in metabolic disease development and insulin resistance

This neuroprotective suppression of glutamate release is mediated by Ca++ channels (P/Q type), a step which is modulated by pkc and not pka