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For some people, especially those with certain genetic variations like the MTHFR mutation, converting cyanocobalamin can be a challenge

This connection has led researchers to focus on better understanding the effect of low vitamin B12 on obesity, insulin resistance, type 2 diabetes, and cardiovascular disease

For example, one theory is that the decrease of estrogen in aging women, blood flow to the connect tissue decreases and lower circulation results in lower collagen production