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Toxicology and Applied Pharmacology

doi: 10.1002/anie.200602866 25 MohanJ.KumarR.RoyI

Its deficiency can result in neurological symptoms like tingling, numbness, and difficulty with coordination

Symptoms Severe vitamin E deficiency results mainly in neurologic symptoms, including impaired balance and coordination (spinocerebellar ataxia), injury to the sensory nerves (peripheral neuropathy), muscle weakness (myopathy), and damage to the retina of the eye (retinopathy)

Notably, the two genes with the strongest correlation, SLC7A11 and SLC3A2 , together encode the cystine/glutamate antiporter system x C , which serves to import cystine, the rate limiting substrate for the formation of GSH 10