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Some pharmacokinetic studies suggest that only around 1.52.5 g of B12 is absorbed from food per meal, while approximately 5% of a 25 g dose and only 1% of a 1,000 g oral dose is effectively absorbed (Devi et al., 2020

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Mary Armonios of the Johns Hopkins Kimmel Cancer Center, maintaining normal telomere length is inversely correlated with immune system abnormalities, and a 2013 review notes that melatonin modulates immune responses by helping to proliferate immunocompetent cells and secrete immune mediators.18 19 Tumor suppression The telomere-lengthening, along with the attendant increase in immune function, may help ward off cancer as well

This precluded a placebo effect, and it produced promising results

For comprehensive longevity protocols, researchers might explore combining 5-amino-1mq with compounds targeting other aging pathways