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Additional information Peer review information Nature Metabolism thanks Dominique Langin and the other, anonymous reviewers for their contribution to the peer review of this work

People with Certain Medications: Long-term use of medications like proton pump inhibitors or metformin can interfere with B12 absorption, leading to a deficiency

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Lipotropic injections are not recommended during pregnancy or breastfeeding due to lack of safety data

To avoid any unpleasant surprises, consider testing your vitamin B12 status at least once, even if you take supplements