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That said, it is important to be transparent: there are no large-scale randomized controlled trials proving that lipotropic injections alone produce significant weight loss

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This extended duration of action results from the peptide's resistance to enzymatic degradation rather than prolonged circulation, allowing for less frequent dosing while maintaining physiological growth hormone patterns

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By using restricted cubic splines and IGF-1 serum concentrations as a continuous measure we did not find evidence for an association with ALS risk (p-value 0.21, Supplemental Fig