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Activating the focal adhesion kinase (FAK)-paxillin pathway strengthens cellular adhesion, migration, and survival while supporting matrix remodeling and cartilage integrity

10.3390/ijms20194716 442 TyagiA.ChoiY.-Y.ShanL.VinothkannaA.LeeE.-S.ChelliahR.et al

Integrating the RNAseq with the proteomics data, focusing specifically on downregulated genes/proteins, we identified 11 genes that exhibited alterations at both the transcriptional and protein levels (Fig

Mechanistically, alterations in gut microbial metabolites such as SCFAs could affect the integrity of the BBB, induce systemic endotoxemia, and activate microglia so as to impact disease progression

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