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Results Engineering of IgG1 for prolonged plasma half-life By scrutinizing a human FcRn:IgG1 Fc co-crystal structure 21 , we identified three Fc amino acid residues that were substituted with the rationale to improve pH-dependent receptor binding, namely Q311R, M428E and N434W (REW) (Fig

Italicized numbers in the top right of each dose response are IGF-1 concentrations at the beginning and end of each treatment period

Current omics-based biomarkers for cholangiocarcinoma