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P.MicheliF.et al

Notably, in this loop, pyroptosis is primarily responsible for the rapid amplification of acute inflammation, whereas ferroptosis drives disease progression toward an irreversible direction through sustained depletion of structural cells

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In patients with PCOS, endometrial GLUT4 expression is decreased, and glucose transport and utilization are impaired, leading to endometrial energy metabolism disorders, which in turn affect the establishment of endometrial tolerance