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The safety profile was acceptable, with gastrointestinal side effects being the most common, consistent with amylin analogues

The compound is referenced across a wide spectrum of preclinical models, with most literature focusing on three thematic areas: Skin biology: Studies on dermal fibroblast behaviour, collagen and elastin synthesis pathways, and extracellular matrix remodelling Gene expression modulation: Research examining the compounds reported activity across thousands of genes in genome-wide expression studies Antioxidant & copper transport: Models exploring its role as a physiological copper carrier and free radical interaction The 50mg and 100mg vial formats make GHK-Cu particularly suitable for extended research protocols where higher peptide volumes are required compared with the typical 510mg formats used for other research compounds

Arch Oral Biol 1975

ClinicalTrials.gov (2023)

A molecule that can activate telomerase or modulate circadian genes is only useful if it reaches its target intact